Read about Inter-alpha Inhibitor Proteins
Stober VP, Lim YP, Opal S, Zhuo L, Kimata K, Garantziotis S. Inter-α-inhibitor Ameliorates Endothelial Inflammation in Sepsis. Lung. 2019 Jun;197(3):361-369.
Chen X, Nakada S, Donahue JE, Chen RH, Tucker R, Qui J, Lim YP, Stopa EG, Stonestreet BS. Neuroprotective effects of inter-alpha inhibitor proteins after hypoxic-ischemic brain injury in neonatal rats. Experimental Neurology 2019 317:244-259.
Htwe SS, Wake H, Liu K, Teshigawara K, Stonestreet B, Lim YP, Nishibori M. Inter-a Inhibitor proteins maintain neutrophils in a resting state by regulating shape and reducing ROS production. Blood Adv. 2018 Aug 14;2(15):1923-1934.
Disdier C, Zhang J, Fukunaga Y, Lim YP, Qiu J, Santoso A, Stonestreet BS. Alterations in inter-alpha inhibitor protein expression after hypoxic-ischemic brain injury in neonatal rats. Int J of Dev Neuroscience 2017 e65, 54-60.
Threlkeld SW, Lim YP, LaRue M, Gaudet C, Stonestreet BS. Immuno-modulator inter-alpha inhibitor proteins ameliorate complex auditory processing deficits in rats with neonatal hypoxic-ischemic brain injury. Brain Behav Immun. 2017 Mar 10; Epub ahead of print.
Shah B A, Migliori A, Kurihara I, Sharma S, Lim YP, Padbury J. Blood Level of Inter-Alpha Inhibitor Proteins Distinguishes Necrotizing Enterocolitis from Spontaneous Intestinal Perforation. J Peds, 2017 Jan; Vol 180,135-140.
Spasova, MA, Chen, X, Sadowska, GB, Horton,ER, Lim, YP, Stonestreet, BS. Ischemia Reduces Inter-Alpha Inhibitor Proteins in the Brain of the Ovine Fetus. Dev. Biology. 2016 Sep 12 doi: 10.1002/dneu.22451 [epub ahead of print]
Chen X, Rivard L, Naqvi S, Nakada S, Padbury JF, Sanchez-Esteban J, Stopa EG, Lim YP, Stonestreet BS. Expression and localization of Inter-alpha Inhibitors in rodent brain. Neuroscience. 2016 Jun 2;324:69-81.
Gaudet CM, Lim YP, Stonestreet BS, Threlkeld SW. Effects of age, experience and inter-alpha inhibitor proteins on working memory and neuronal plasticity after neonatal hypoxia-ischemia. Behav Brain Res. 2016 Apr 1;302:88-99.
Chaaban H, Keshari RS, Silasi-Mansat R, Popescu NI, Mehta-D’Souza P, Lim YP, Lupu F. Inter-α inhibitor protein and its associated glycosaminoglycans protect against histone-induced injury. Blood. 2015 Apr 2;125(14):2286-96.
Threlkeld SW, Gaudet CM, La Rue ME, Dugas E, Hill CA, Lim YP, Stonestreet BS. Effects of inter-alpha inhibitor proteins on neonatal brain injury: Age, task and treatment dependent neurobehavioral outcomes. Exp Neurol. 2014 Nov;261:424-33.
Spasova MS, Sadowska GB, Threlkeld SW, Lim YP, Stonestreet BS. Ontogeny of inter-alpha inhibitor proteins in ovine brain and somatic tissues. Exp Biol Med 2014 Jun;239(6):724-36.
Lazrak A, Jurkuvenaite A, Ness EC, Zhang S, Woodworth BA, Muhlebach MS, Stober VP, Lim YP, Garantziotis S, Matalon S. Inter-α-inhibitor blocks epithelial sodium channel activation and decreases nasal potential differences in ΔF508 mice. Am J
Respir Cell Mol Biol. 2014 May;50(5):953-62.
Opal SM, Lim YP, Cristofaro P, Artenstein AW, Kessimian N, Delsesto D, Parejo N, Palardy JE, Siryaporn E. Inter-α inhibitor proteins: a novel therapeutic strategy for experimental anthrax infection. Shock. 2011 Jan;35(1):42-4.
Chaaban H, Shin M, Sirya E, Lim YP, Caplan M, Padbury JF. Inter-alpha inhibitor protein level in neonates predicts necrotizing enterocolitis. J Pediatr. 2010 Nov;157(5):757-61.
Singh K, Zhang LX, Bendelja K, Heath R, Murphy S, Sharma S, Padbury JF, Lim YP. Inter-alpha inhibitor protein administration improves survival from neonatal sepsis in mice. Pediatr Res. 2010 Sep;68(3):242-7
Koraka P, Lim YP, Shin MD, Setiati TE, Mairuhu AT, van Gorp EC, Soemantri A, Osterhaus AD, Martina BE. Plasma levels of inter-alpha inhibitor proteins in children with acute Dengue virus infection. PLoS One. 2010 Apr 6;5(4):e9967.
Adair JE, Stober V, Sobhany M, Zhuo L, Roberts JD, Negishi M, Kimata K, Garantziotis S. Inter-alpha-trypsin inhibitor promotes bronchial epithelial repair after injury through vitronectin binding. J Biol Chem. 2009 Jun 19;284(25):16922-30.
Chaaban H, Singh K, Huang J, Siryaporn E, Lim YP, Padbury JF. The role of inter-alpha inhibitor proteins in the diagnosis of neonatal sepsis. J Pediatr.2009 Apr;154(4):620-622.
Garantziotis S, Hollingsworth JW, Ghanayem RB, Timberlake S, Zhuo L, Kimata K, Schwartz DA. Inter-alpha-trypsin inhibitor attenuates complement activation and complement-induced lung injury. J Immunol. 2007 Sep 15;179(6):4187-92.
Rucevic M, Fast LD, Jay GD, Trespalcios FM, Sucov A, Siryaporn E, Lim YP. Altered levels and molecular forms of granzyme K in plasma from septic patients. Shock. 2007 May;27(5):488-93.
Opal SM, Lim YP, Siryaporn E, Moldawer LL, Pribble JP, Palardy JE, Souza S.Longitudinal studies of inter-alpha inhibitor proteins in severely septic patients: a potential clinical marker and mediator of severe sepsis. Crit Care Med. 2007 Feb;35(2):387-92.
Josic D, Brown MK, Huang F, Lim YP, Rucevic M, Clifton JG, Hixson DC. Proteomic characterization of inter-alpha inhibitor proteins from human plasma. Proteomics. 2006 May;6(9):2874-85.
Opal SM, Artenstein AW, Cristofaro PA, Jhung JW, Palardy JE, Parejo NA, Lim YP. Inter-alpha-inhibitor proteins are endogenous furin inhibitors and provide protection against experimental anthrax intoxication. Infect Immun. 2005 Aug;73(8):5101-5.
Lim YP, Josic D, Callanan H, Brown J, Hixson DC. Affinity purification and enzymatic cleavage of inter-alpha inhibitor proteins using antibody and elastase immobilized on CIM monolithic disks. J Chromatogr A. 2005 Feb 11;1065(1):39-43.
Wu R, Cui X, Lim YP, Bendelja K, Zhou M, Simms HH, Wang P. Delayed administration of human inter-alpha inhibitor proteins reduces mortality in sepsis. Crit Care Med. 2004 Aug;32(8):1747-52.
Lim YP, Bendelja K, Opal SM, Siryaporn E, Hixson DC, Palardy JE. Correlation between mortality and the levels of inter-alpha inhibitors in the plasma of patients with severe sepsis. J Infect Dis. 2003 Sep 15;188(6):919-26.
Baek YW, Brokat S, Padbury JF, Pinar H, Hixson DC, Lim YP. Inter-alphainhibitor proteins in infants and decreased levels in neonatal sepsis. J Pediatr. 2003 Jul;143(1):11-5.
Yang S, Lim YP, Zhou M, Salvemini P, Schwinn H, Josic D, Koo DJ, Chaudry IH, Wang P. Administration of human inter-alpha-inhibitors maintains hemodynamic stability and improves survival during sepsis. Crit Care Med. 2002 Mar;30(3):617-22.